Advanced Daily Defense Serum safety rating

Advanced Daily Defense Serum safety rating | Greenlens

All 592 cleaner options, safest first We show the best 12, including the strongest on each axis.

Every rater, every axis

Ingredient safety

raters agree

Independent — not funded by the brands it rates. Auto-linked to this product, not yet human-reviewed. Checked this week. about this rater →
Independent — not funded by the brands it rates. Auto-linked to this product, not yet human-reviewed. Checked this week. about this rater →
Independent — not funded by the brands it rates. Auto-linked to this product, not yet human-reviewed. Checked this week. about this rater →
A government authority. Auto-linked to this product, not yet human-reviewed. Checked this week. about this rater →

Also screened, nothing found: ECHA SVHC Candidate List · California Proposition 65 · IARC Monographs · ANSES Endocrine Disruptors · US NTP Report on Carcinogens · EU Harmonised Classification (CLP Annex VI)

Recognized on a safer-ingredients list: US EPA Safer Choice recognizes 50% of ingredients as safer choices — a marker, never a score.

Environmental

Also screened, nothing found: EU Microplastics Restriction

Labor

Run by a nonprofit. Auto-linked to this product, not yet human-reviewed. This rates Cetaphil as a company and applies to everything they make, not this product alone. Checked this week. about this rater →

Coverage & match quality

5 ratings · 2 of 4 axes

Some ratings rest on an automatic match that has not been human-reviewed.
Fewer raters reach smaller-brand products, so a missing rating is not a clean bill of health, only a gap.

Weighted by what you care about

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composite recomputes live

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Ingredient safety1.0×

Environmentalno rating

No rater covers this axis for this product, so its weight can't move the score.

Labor1.0×

Packagingno rating

No rater covers this axis for this product, so its weight can't move the score.

0 means ignored. Higher = more weight in your composite.

Ingredients, decoded

Data availability

Robust16 of 16 characterized

Our sources have reference data on all 16 listed ingredients.

Worth a look (1)

CITRIC ACIDfragrance · chelating · bufferingraters disagree
Health Canada Hotlist — restrictedflagged by 1 of 9 lists →

No flags in our sources (15)

What these ingredient tags mean (2)

These describe what an ingredient is, not whether it is a problem. The stance marks above are the ratings; these are not.

humectantHYDROLYZED HYALURONIC ACID
- HYDROLYZED HYALURONIC ACID: A humectant that holds a large amount of water at the skin surface. Chylińska N, Maciejczyk M, "Hyaluronic Acid and Skin: Its Role in Aging and Wound-Healing Processes", Gels 2025;11(4):281, DOI 10.3390/gels11040281, PMID 40277717, open access: hyaluronic acid's "high osmotic activity and anionic structure enable it to bind large amounts of water", and "sodium and potassium hyaluronate are widely used in moisturizing products". The same review notes that high-molecular-weight hyaluronic acid does not penetrate the deeper layers.
soothingNIACINAMIDE, ALLANTOIN
- NIACINAMIDE: A vitamin B3 form that supports the skin barrier and has anti-inflammatory activity; it turns up in products aimed at acne, rosacea and eczema. Camillo L, Zavattaro E, Savoia P, "Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond", Medicina (Kaunas) 2025;61(2):254, DOI 10.3390/medicina61020254, PMID 40005371, open access: it "is extensively used in ... the treatment of dermatological conditions such as blistering diseases, atopic dermatitis, rosacea, and acne vulgaris", and contributes to reducing inflammation. On the acne evidence specifically: Liu H, Yu H, Xia J, Liu L, Liu GJ, Sang H, Peinemann F, "Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne", Cochrane Database Syst Rev 2020;5:CD011368, DOI 10.1002/14651858.CD011368.pub2, PMID 32356369, records "low-quality evidence" for every nicotinamide comparison it could pool, and none of its four nicotinamide studies measured the physician global assessment at all.
- ALLANTOIN: A skin protectant used at low levels in products aimed at irritated skin. FDA OTC skin protectant monograph, 21 CFR 347.10(a), lists allantoin as a skin-protectant active at 0,5 to 2%. Its labelled indications are 21 CFR 347.50(b)(1), "temporarily protects minor: cuts, scrapes, burns", and (b)(2), which covers chafed, chapped or cracked skin. The monograph does not give it the "minor skin irritation and itching" wording; that one belongs to colloidal oatmeal, sodium bicarbonate and one combination, and to topical starch without the itching half.