Cream Developer 40-Volume

These describe what an ingredient is, not whether it is a problem. The stance marks above are the ratings; these are not.

• comedogenic in testingisopropyl palmitate

  • isopropyl palmitate: A light emollient named among the pore-clogging materials in the rabbit-ear assay. Fulton JE Jr, Pay SR, Fulton JE 3rd, "Comedogenicity of current therapeutic products, cosmetics, and ingredients in the rabbit ear", J Am Acad Dermatol 1984;10(1):96-105, PMID 6229554. The openly readable abstract names this ingredient among its "ingredient offenders", in prose and without a numeric rating: "Ingredient offenders include isopropyl myristate and its analogs, such as isopropyl palmitate, isopropyl isostearate, butyl stearate, isostearyl neopentanoate, myristyl myristate..." The rabbit-ear assay rates raw ingredients and does not predict how a finished formula behaves on human skin.

• common irritantbenzoyl peroxide

  • benzoyl peroxide: An over-the-counter acne drug; its own label names irritation, dryness and peeling as things to expect. FDA OTC acne drug monograph, 21 CFR 333 subpart D. Section 333.350(c)(4)(ii): "skin irritation may occur, characterized by redness, burning, itching, peeling, or possibly swelling." Section 333.350(c)(1)(ii): "skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time." Section 333.350(d)(1): "because excessive drying of the skin may occur, start with one application daily", and "if bothersome dryness or peeling occurs, reduce application". The same wording carries into OTC Monograph M006, Topical Acne Drug Products.