Anti Aging Night Cream (2019 formulation)

These describe what an ingredient is, not whether it is a problem. The stance marks above are the ratings; these are not.

• common irritantPROPYLENE GLYCOL

  • PROPYLENE GLYCOL: A solvent that shows up in patch-test clinics, more often as irritation than as allergy. American Contact Dermatitis Society, Allergen of the Year 2018 (Jacob SE, Scheman A, McGowan MA, Dermatitis 2018;29(1):3-5).

• fragrance materialLIMONENE, LINALOOL

  • LIMONENE: A citrus-smelling fragrance component named separately on the label; the one name covers three related isomers. EU Regulation (EC) 1223/2009, Annex III entry 88: a fragrance substance whose presence must be indicated in the list of ingredients above 0,001% in leave-on and 0,01% in rinse-off products, because of established contact-allergy risk. That entry carries transition footnote (37): stock that does not comply, lawfully placed on the Union market before the 31 July 2026 cut-off, may still be made available until 31 July 2028. It is marked on the racemic dl-limonene/Dipentene line and the (S)-(l-limonene) line, but NOT the (R)-p-mentha-1,8-diene (d-limonene) line, CAS 5989-27-5, whose duty was already running as entry 88 before Commission Regulation (EU) 2023/1545 and so needed no transition. All three isomers are declared under the single glossary name "Limonene", so that name on a label does not identify which of them is present.
  • LINALOOL: A floral fragrance component named separately on the label. EU Regulation (EC) 1223/2009, Annex III entry 84: a fragrance substance whose presence must be indicated in the list of ingredients above 0,001% in leave-on and 0,01% in rinse-off products, because of established contact-allergy risk.

• undeclared fragrance blendPARFUM/FRAGRANCE

  • PARFUM/FRAGRANCE: A blend the label does not itemize, so what is in it cannot be read from the ingredient list. EU Regulation (EC) 1223/2009 permits the collective term "parfum"; the SCCS Opinion on Fragrance Allergens (SCCS/1459/11) reviews the contact-allergy evidence for the substances it can contain.

• rich occlusiveDIMETHICONE

  • DIMETHICONE: A silicone that forms a film on the surface of the skin without an oily feel. FDA OTC skin protectant monograph, 21 CFR 347.10(g), lists dimethicone as a skin protectant at 1 to 30%.

• humectantGLYCERIN, SODIUM HYALURONATE, SODIUM PCA, UREA

  • GLYCERIN: A humectant, and one of the two ingredients a comparison of moisturiser components found made a significant difference to skin hydration. FDA OTC skin protectant monograph, 21 CFR 347.10(h), lists glycerin as a skin protectant at 20 to 45%. On the humectant half: Jeong CB, Han JY, Cho JC, Suh KD, Nam GW, "Analysis of electrical property changes of skin by oil-in-water emulsion components", Int J Cosmet Sci 2013;35(4):402-410, DOI 10.1111/ics.12059, PMID 23621673, found that "glycerine and urea showed significant skin hydration effects compared with other humectants".
  • SODIUM HYALURONATE: A humectant that holds a large amount of water at the skin surface. Chylińska N, Maciejczyk M, "Hyaluronic Acid and Skin: Its Role in Aging and Wound-Healing Processes", Gels 2025;11(4):281, DOI 10.3390/gels11040281, PMID 40277717, open access: hyaluronic acid's "high osmotic activity and anionic structure enable it to bind large amounts of water", and "sodium and potassium hyaluronate are widely used in moisturizing products". The same review notes that high-molecular-weight hyaluronic acid does not penetrate the deeper layers.
  • SODIUM PCA: The salt of PCA, one of the water-holding substances the outer layer of skin makes for itself. Dörner C, Steinbinder J, Sachslehner AP, Sukseree S, Eckhart L, "Amino Acid Metabolism of the Skin: Control by Specific Enzymes and Contribution to Protective Functions", Metabolites 2025;15(9):601, DOI 10.3390/metabo15090601, open access, section "Glutamine Is Converted to Pyrrolidone Carboxylic Acid, a Component of the NMF": "pyrrolidone carboxylic acid (PCA), also known as pyroglutamic acid or 5-oxoproline, accumulates in the stratum corneum."
  • UREA: A humectant the skin already makes; at higher levels it also softens thickened skin. StatPearls, "Moisturizers", NCBI Bookshelf NBK545171, updated 12 February 2024: "Urea is a component of NMF. The addition of urea to moisturizers helps with the absorption of water into the stratum corneum." The FDA label for prescription-strength urea calls it keratolytic and states that its mechanism of action is not yet known.

• barrier lipidCERAMIDE 2

  • CERAMIDE 2: One of the lipid families the skin barrier is actually built from. Feingold KR and Elias PM, "The role of ceramides in the disruption of the cutaneous permeability barrier, a common manifestation of skin disorders", J Lipid Res 2024;65(8):100593, DOI 10.1016/j.jlr.2024.100593, open access: the barrier lipid matrix "by weight is approximately 50% ceramides, 25% cholesterol, and 15% free fatty acids".